The Use of Stem Cells to Treat Myocardial Necrosis

When an obstruction of a coronary vessel occurs, there is a possibility of myocardial necrosis. In adults the monocytes located in the cardiac tissue are not able to replicate. There are smooth muscle and endothelial cells which can replicate, but cause the formation of scar tissue. Using primitive stem cells, could be a way to regrow the tissue resulting from necrosis. Primitive stem cells are located on the organs usually of the fetus. They have functional plasticity in which they are able to move to different areas in the body when needed. In this experiment bone marrow was extracted from mice and then tested with the c-kit expression, which identifies certain proteins located in the bone marrow. A side population of cells. or SP cells, were used from the bone marrow and from these the cells RNA was used and tested using PCR (Polymerase Chain Reaction) and primers. The SP cells isolated earlier in the experiment were then injected into female mice and after two and a half months the coronary artery of the female mice was occluded. The hearts were then extracted after two weeks and the hearts of those mice that were still alive at that time were stained with x-gal. The x-gal showed that these SP cells migrated to the injured parts of the heart by using the circulatory system. This is important for nursing because these primitive stem cells could help to be an alternate therapy that can be used to help patients. The ability of having the heart to regrow could reduce theShow MoreRelatedPlasticity Of Mesenchymal Stem Cell3461 Words   |  14 PagesPLASTICITY OF MESENCHYMAL STEM CELL INTRODUCTION Mesenchymal stem cells (MSC), also regarded as marrow stromal cells, are multipotent adult stem cells that are able to differentiate into limited mesodermal lineage and are able to self renew. MSCs possess characteristics that make them useful in regenerative medicine including, immunomodulation, secretion profile and homing characteristics. Depending on where they are used, these characteristics can have a positive and negative influence on the diseaseRead MoreComplications and Prevalence of Diabetes1391 Words   |  6 Pages Diabetes is a chronic disease where in there is high sugar level in blood either due to insufficient insulin production or to the inability of cells to respond to insulin. Diabetes can cause a lot of long-term complications that affect different parts of the body. It can cause eye complications such as glaucoma, cataracts, diabetic retinopathy, and blindness. Foot complications that can lead to amputation can also result from uncontrolled diabetes. Skin infect ions and disorders are more common toRead MoreA Case Study 7 Mrs Mei Li Huong2191 Words   |  9 PagesHuong 1. The Cell cycle consists of various phases, G 1 (growth preparation of DNA), S (DNA synthesis), G 2 (cell preparation to divide), Mitosis (where chromosomes separate the cell divides) and G0 (where non-dividing cells exit from the cycle). Cytotoxic therapy is the use of chemotherapy to disturb cellular growth by causing damage to the DNA and impairing cell function (Dougherty Lister, 2011 p. 870). By affecting the growth and replication of these cells, treatments for patientsRead More Ephedrine: The Weight Loss Wonder Drug? Essay2457 Words   |  10 Pagesproducts to enhance their diets. A recent estimate indicates, â€Å"Americans are spending some $6 billion annually on nutritional supplements, and the market is growing by 20% every year† (Zahn, 1997). Of these supplements, the increase in herbal remedy use is most dramatic. Zahn holds that the increase can be attributed to the widely held belief that herbal substances are healthy and harmless because of their natural origins (1997). Unfortunately, research on these supplements, herbal or otherwise,Read MoreEssay on Pathophysiology Exam 15529 Words   |  23 Pagesexperiencing muscle atrophy following 2 weeks in traction after a motor vehicle accident. Which of the following factors has most likely contributed to the atrophy of the clients muscle cells? a. Reduced oxygen consumption and cellular function that ensures muscle cell survival b. A reduction of skeletal muscle use secondary to the traction treatment c. Denervation of the affected muscles during the time of traction d. High levels of insulin and IGF-1 in the clients blood during immobilization Read MoreSocm Study Guide Essay30404 Words   |  122 Pagesorganisms. A. Responsiveness – organisms respond to changes in their immediate environment (long term changes is adaptability) B. Growth – over a lifetime, organisms grow larger through an increase in size or number of cells. Differentiation is when cells have specialized functions C. Reproduction – Organisms reproduce, creating subsequent generations of similar organisms D. Movement – Organisms are capable of movement a. Internal – moving food, blood, or other materials